Hepatic drug-metabolizing enzymes and drug transporters in Wilson's disease patients with liver failure.

ABSTRACT:

Background

Wilson's disease is a genetic disorder inherited in a recessive manner, caused by mutations in the copper-transporter ATP7B. Although it is a well-known disease, currently available treatments are far from satisfactory and their efficacy varies in individual patients. Due to the lack of information about drug-metabolizing enzymes and drug transporters profile in Wilson's disease livers, we aimed to evaluate the mRNA expression and protein abundance of selected enzymes and drug transporters in this liver disorder.

Methods

We analyzed gene expression (qPCR) and protein abundance (LC-MS/MS) of 14 drug-metabolizing enzymes and 16 drug transporters in hepatic tissue from Wilson's disease patients with liver failure (n = 7, Child-Pugh class B and C) and metastatic contr

SUBMITTER: Szelag-Pieniek S 

PROVIDER: S-EPMC8460590 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature