Corticospinal Tract Microstructure Predicts Distal Arm Motor Improvements in Chronic Stroke.

ABSTRACT:

Background and purpose

The corticospinal tract (CST) is a crucial brain pathway for distal arm and hand motor control. We aimed to determine whether a diffusion tensor imaging (DTI)-derived CST metric predicts distal upper extremity (UE) motor improvements in chronic stroke survivors.

Methods

We analyzed clinical and neuroimaging data from a randomized controlled rehabilitation trial. Participants completed clinical assessments and neuroimaging at baseline and clinical assessments 4 months later, postintervention. Using univariate linear regression analysis, we determined the linear relationship between the DTI-derived CST fractional anisotropy asymmetry (FAasym) and the percentage of baseline change in log-transformed average Wolf Motor Function Test time for distal items (

SUBMITTER: Kim B 

PROVIDER: S-EPMC8460613 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature