Quantitative assessment of sensitizing potency using a dose-response adaptation of GARDskin.

ABSTRACT: Hundreds of chemicals have been identified as skin sensitizers. These are chemicals that possess the ability to induce hypersensitivity reactions in humans, giving rise to a condition termed allergic contact dermatitis. The capacity to limit hazardous exposure to such chemicals depends upon the ability to accurately identify and characterize their skin sensitizing potency. This has traditionally been accomplished using animal models, but their widespread use offers challenges from both an ethical and a scientific perspective. Comprehensive efforts have been made by the scientific community to develop new approach methodologies (NAMs) capable of replacing in vivo assays, which have successfully yielded several methods that can identify skin sensitizers. However, there is still a lack of new

SUBMITTER: Gradin R 

PROVIDER: S-EPMC8460622 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature