Aggravation of fibrin deposition and microthrombus formation within the graft during kidney transplantation.

ABSTRACT: In kidney transplantation, microthrombi and fibrin deposition may lead to local perfusion disorders and subsequently poor initial graft function. Microthrombi are often regarded as donor-derived. However, the incidence, time of development, and potential difference between living donor kidneys (LDK) and deceased donor kidneys(DDK), remains unclear. Two open-needle biopsies, taken at preimplantation and after reperfusion, were obtained from 17 LDK and 28 DDK transplanted between 2005 and 2008. Paraffin-embedded sections were immunohistochemically stained with anti-fibrinogen antibody. Fibrin deposition intensity in peritubular capillaries(PTC) and glomeruli was categorized as negative, weak, moderate or strong and the number of microthrombi/mm² was quantified. Reperfusion biopsie

SUBMITTER: van den Berg TAJ 

PROVIDER: S-EPMC8460629 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature