Early probiotic supplementation with B. infantis in breastfed infants leads to persistent colonization at 1 year.

ABSTRACT:

Background

Recent studies have reported a dysfunctional gut microbiome in breastfed infants. Probiotics have been used in an attempt to restore the gut microbiome; however, colonization has been transient, inconsistent among individuals, or has not positively impacted the host's gut.

Methods

This is a 2-year follow-up study to a randomized controlled trial wherein 7-day-old infants received 1.8 × 10¹⁰ colony-forming unit Bifidobacterium longum subsp. infantis (B. infantis) EVC001 (EVC) daily for 21 days or breast milk alone (unsupplemented (UNS)). In the follow-up study, mothers (n = 48) collected infant stool at 4, 6, 8, 10, and 12 months postnatal and completed the health-diet questionnaires.

Results

Fecal B. infantis was 2.5-3.5 log units higher at 6-12

SUBMITTER: O'Brien CE 

PROVIDER: S-EPMC8460680 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature