High CYP27A1 expression is a biomarker of favorable prognosis in premenopausal patients with estrogen receptor positive primary breast cancer.

ABSTRACT: 27-hydroxycholesterol (27HC), synthesized from cholesterol by the enzyme CYP27A1, differentially impacts estrogen receptor positive (ER+) breast cancer (BC) cell growth depending on estrogen levels. This study examined the association between CYP27A1 expression and prognosis in a cohort of 193 premenopausal patients with lymph node-negative primary BC with limited exposure to adjuvant systemic cancer treatments. In multivariable analyses among patients with ER+ tumors, high CYP27A1 protein and mRNA expressions were associated with four- and eight-fold reductions in the incidence of distant recurrence-free survival events: HR_adj = 0.26, 95% CI = 0.07-0.93 and HR_adj = 0.13, 95% CI = 0.03-0.60, respectively. In vitro studies revealed that 27HC treatment potently inhibite

SUBMITTER: Inasu M 

PROVIDER: S-EPMC8460751 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature