In silico Identification of Key Factors Driving the Response of Muscle Sensory Neurons to Noxious Stimuli.

ABSTRACT: Nociceptive nerve endings embedded in muscle tissue transduce peripheral noxious stimuli into an electrical signal [i.e., an action potential (AP)] to initiate pain sensations. A major contributor to nociception from the muscles is mechanosensation. However, due to the heterogeneity in the expression of proteins, such as ion channels, pumps, and exchangers, on muscle nociceptors, we currently do not know the relative contributions of different proteins and signaling molecules to the neuronal response due to mechanical stimuli. In this study, we employed an integrated approach combining a customized experimental study in mice with a computational model to identify key proteins that regulate mechanical nociception in muscles. First, using newly collected data from somatosensory recordings in

SUBMITTER: Nagaraja S 

PROVIDER: S-EPMC8461020 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature