Thromboxane A₂ receptors contribute to the exaggerated exercise pressor reflex in male rats with heart failure.

ABSTRACT: Mechanical and metabolic signals associated with skeletal muscle contraction stimulate the sensory endings of thin fiber muscle afferents and produce reflex increases in sympathetic nerve activity and blood pressure during exercise (i.e., the exercise pressor reflex; EPR). The EPR is exaggerated in patients and animals with heart failure with reduced ejection fraction (HF-rEF) and its activation contributes to reduced exercise capacity within this patient population. Accumulating evidence suggests that the exaggerated EPR in HF-rEF is partially attributable to a sensitization of mechanically activated channels produced by thromboxane A₂ receptors (TxA₂ -Rs) on those sensory endings; however, this has not been investigated. Accordingly, the purpose of this investigatio

SUBMITTER: Butenas ALE 

PROVIDER: S-EPMC8461035 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature