High Na⁺ Environments Impair Phagocyte Oxidase-Dependent Antibacterial Activity of Neutrophils.

ABSTRACT: Infection and inflammation can augment local Na⁺ abundance. These increases in local Na⁺ levels boost proinflammatory and antimicrobial macrophage activity and can favor polarization of T cells towards a proinflammatory Th17 phenotype. Although neutrophils play an important role in fighting intruding invaders, the impact of increased Na⁺ on the antimicrobial activity of neutrophils remains elusive. Here we show that, in neutrophils, increases in Na⁺ (high salt, HS) impair the ability of human and murine neutrophils to eliminate Escherichia coli and Staphylococcus aureus. High salt caused reduced spontaneous movement, degranulation and impaired production of reactive oxygen species (ROS) while leaving neutrophil viability unchanged.

SUBMITTER: Krampert L 

PROVIDER: S-EPMC8461097 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature