Thymic T-Cell Production Is Associated With Changes in the Gut Microbiota in Young Chicks.

ABSTRACT: Increasing studies show that gut microbiota play a central role in immunity, although the impact of the microbiota on mediation of thymic T cells throughout life is not well understood. Chickens have been shown to be a valuable model for studying basic immunology. Here, we show that changes in the gut microbiota are associated with the development of thymic T cells in young chickens. Our results showed that T-cell numbers in newborn chicks sharply increased from day 0 and peaked at day 49. Interestingly, the α-diversity score pattern of change in gut microbiota also increased after day 0 and continued to increase until day 49. We found that early antibiotic treatment resulted in a dramatic reduction in gut alpha diversity: principal component analysis (PCA) showed that antibiotic treatment

SUBMITTER: Cheng J 

PROVIDER: S-EPMC8461177 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature