Maternal vitamin B₁₂, folate during pregnancy and neurocognitive outcomes in young adults of the Pune Maternal Nutrition Study (PMNS) prospective birth cohort: study protocol.

ABSTRACT:

Introduction

The Developmental Origins of Health and Disease (DOHaD) hypothesis proposes that intrauterine and early life exposures significantly influence fetal development and risk for disease in later life. Evidence from prospective birth cohorts suggests a role for maternal B₁₂ and folate in influencing neurocognitive outcomes in the offspring. In the Indian setting, B₁₂ deficiency is common during the pregnancy while rates of folate deficiency are lower. The long-term influences of maternal nutrition during the pregnancy on adult neurocognitive outcomes have not been examined. The Pune Maternal Nutrition Study (PMNS) is a preconceptional birth cohort into its 24th year and is considered a unique resource to study the DOHaD hypothesis. We found an associat

SUBMITTER: Behere RV 

PROVIDER: S-EPMC8461273 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature