Sex as a prognostic factor for mortality in critically ill adults with sepsis: a systematic review and meta-analysis.

ABSTRACT:

Objective

To assess the role of sex as an independent prognostic factor for mortality in patients with sepsis admitted to intensive care units (ICUs).

Design

Systematic review and meta-analysis.

Data sources

MEDLINE, Embase, Web of Science, ClinicalTrials.gov and the WHO Clinical Trials Registry from inception to 17 July 2020.

Study selection

Studies evaluating independent associations between sex and mortality in critically ill adults with sepsis controlling for at least one of five core covariate domains prespecified following a literature search and consensus among experts.

Data extraction and synthesis

Two authors independently extracted and assessed the risk of bias using Quality In Prognosis Studies tool. Meta-analysis was performed by pooling adju

SUBMITTER: Antequera A 

PROVIDER: S-EPMC8461281 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature