Regulation of Biofilm Exopolysaccharide Production by Cyclic Di-Guanosine Monophosphate.

ABSTRACT: Many bacterial species in nature possess the ability to transition into a sessile lifestyle and aggregate into cohesive colonies, known as biofilms. Within a biofilm, bacterial cells are encapsulated within an extracellular polymeric substance (EPS) comprised of polysaccharides, proteins, nucleic acids, lipids, and other small molecules. The transition from planktonic growth to the biofilm lifecycle provides numerous benefits to bacteria, such as facilitating adherence to abiotic surfaces, evasion of a host immune system, and resistance to common antibiotics. As a result, biofilm-forming bacteria contribute to 65% of infections in humans, and substantially increase the energy and time required for treatment and recovery. Several biofilm specific exopolysaccharides, including cellulose, alg

SUBMITTER: Poulin MB 

PROVIDER: S-EPMC8461298 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature