Association Between Severity of Leptospirosis and Subsequent Major Autoimmune Diseases: A Nationwide Observational Cohort Study.

ABSTRACT:

Introduction

Infections play a role in autoimmune diseases (AD). Leptospirosis has been linked to the trigger of systemic lupus erythematosus.

Objective

To investigate subsequent risk of major AD in hospitalized Taiwanese for Leptospirosis.

Methods

Retrospective observational cohort study was employed. The enrolled period was from 2000 to 2012. In the main model, we extracted 4026 inpatients with leptospirosis from the Taiwan National Health Insurance Research Database (NHIRD) and 16,104 participants without leptospirosis at a 1:4 ratio propensity-score matched (PSM) by age, gender, index year, and comorbidities. The follow-up period was defined as the time from the initial diagnosis of leptospirosis to major AD occurrence or 2013. This study was re-analyzed by freque

SUBMITTER: Chen CC 

PROVIDER: S-EPMC8461302 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature