Autophagy as a Mechanism for Adaptive Prediction-Mediated Emergence of Drug Resistance.

ABSTRACT: Drug resistance is a major problem in treatment of microbial infections and cancers. There is growing evidence that a transient drug tolerant state may precede and potentiate the emergence of drug resistance. Therefore, understanding the mechanisms leading to tolerance is critical for combating drug resistance and for the development of effective therapeutic strategy. Through laboratory evolution of yeast, we recently demonstrated that adaptive prediction (AP), a strategy employed by organisms to anticipate and prepare for a future stressful environment, can emerge within 100 generations by linking the response triggered by a neutral cue (caffeine) to a mechanism of protection against a lethal agent (5-fluoroorotic acid, 5-FOA). Here, we demonstrate that mutations selected across multiple

SUBMITTER: Nivedita N 

PROVIDER: S-EPMC8461305 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature