Construction of Novel Methylation-Driven Gene Model and Investigation of PARVB Function in Glioblastoma.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is characterized by widespread genetic and transcriptional heterogeneity. Aberrant DNA methylation plays a vital role in GBM progression by regulating gene expression. However, little is known about the role of methylation and its association with prognosis in GBM. Our aim was to explore DNA methylation-driven genes (DMDGs) and provide evidence for survival prediction and individualized treatment of GBM patients.

Methods

Use of the MethylMix R package identified DMDGs in GBM. The prognostic signature of DMDGs based on the risk score was constructed by multivariate Cox regression analysis. Receiver operating characteristics (ROC) curve and C-index were applied to assess the predictive performance of the DMDG prognostic signature. The p

SUBMITTER: Yu W 

PROVIDER: S-EPMC8461318 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature