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Dataset on transcriptomic profiling of cholestatic liver injury induced by food additives and a cosmetic ingredient.


ABSTRACT: The provided dataset describes the differential gene expression profile of human hepatoma HepaRG cells cultured in monolayer configuration upon treatment with chemical compounds with cholestatic potential, including food additives sunset yellow and tartrazine and cosmetic ingredient triclosan, while being exposed to a highly concentrated bile acid mixture. Whole genome microarray Affymetrix Human U133 plus 2.0 was used to obtain the raw data followed by normalization, summarization and background adjustments by means of Robust Multichip Average Express software. Raw data of the different conditions were included as .CEL files in the Gene Expression Omnibus with accession number GSE169072. These data may serve as the basis for further refinement studies to establish an adequate transcriptomic signature of chemical-induced cholestasis fit-for-purpose in screening the cholestatic liability of different types of chemical compounds.

SUBMITTER: Gijbels E 

PROVIDER: S-EPMC8461341 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Dataset on transcriptomic profiling of cholestatic liver injury induced by food additives and a cosmetic ingredient.

Gijbels Eva E   Devisscher Lindsey L   Vinken Mathieu M  

Data in brief 20210917


The provided dataset describes the differential gene expression profile of human hepatoma HepaRG cells cultured in monolayer configuration upon treatment with chemical compounds with cholestatic potential, including food additives sunset yellow and tartrazine and cosmetic ingredient triclosan, while being exposed to a highly concentrated bile acid mixture. Whole genome microarray Affymetrix Human U133 plus 2.0 was used to obtain the raw data followed by normalization, summarization and backgroun  ...[more]

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