Ontology highlight
ABSTRACT:
SUBMITTER: Kawahara K
PROVIDER: S-EPMC8461355 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Kawahara Kenta K Nagata Masashi M Yoshida Ryoji R Hirosue Akiyuki A Tanaka Takuya T Matsuoka Yuichiro Y Arita Hidetaka H Nakashima Hikaru H Sakata Junki J Yamana Keisuke K Kawaguchi Sho S Gohara Shunsuke S Nagao Yuka Y Hirayama Masatoshi M Takahashi Nozomu N Hirayama Mayumi M Nakayama Hideki H
Biochemistry and biophysics reports 20210921
We aimed to determine the functional role of the miRNA, which affects drug sensitivity to 5-FU in oral squamous cell carcinoma (OSCC), using two types of 5-FU-resistant and parental OSCC cell lines. MiRNA microarray data showed that miR-30a was significantly upregulated in two resistant cell lines. Therefore, we investigated the effects and molecular mechanism of miR-30a on 5-FU sensitivity. Stable overexpression of miR-30a in parental OSCC cells decreased cell proliferation and attenuated drug ...[more]