Time since SARS-CoV-2 infection and humoral immune response following BNT162b2 mRNA vaccination.

ABSTRACT:

Background

To optimise the use of available SARS-CoV-2 vaccines, some advocate delaying second vaccination for individuals infected within six months. We studied whether post-vaccination immune response is equally potent in individuals infected over six months prior to vaccination.

Methods

We tested serum IgG binding to SARS-CoV-2 spike protein and neutralising capacity in 110 healthcare workers, before and after both BNT162b2 messenger RNA (mRNA) vaccinations. We compared outcomes between participants with more recent infection (n = 18, median two months, IQR 2-3), with infection-vaccination interval over six months (n = 19, median nine months, IQR 9-10), and to those not previously infected (n = 73).

Findings

Both recently and earlier infected participants showed co

SUBMITTER: Appelman B 

PROVIDER: S-EPMC8461365 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature