Mining genome traits that determine the different gut colonization potential of Lactobacillus and Bifidobacterium species.

ABSTRACT: Although the beneficial effects of probiotics are likely to be associated with their ability to colonize the gut, little is known about the characteristics of good colonizers. In a systematic analysis of the comparative genomics, we tried to elucidate the genomic contents that account for the distinct host adaptability patterns of Lactobacillus and Bifidobacterium species. The Bifidobacterium species, with species-level phylogenetic structures affected by recombination among strains, broad mucin-foraging activity, and dietary-fibre-degrading ability, represented niche conservatism and tended to be host-adapted. The Lactobacillus species stretched across three lifestyles, namely free-living, nomadic and host-adapted, as characterized by the variations of bacteria

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC8461469 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature