Prognosis Associated With Luminal and Basal Subtypes of Metastatic Prostate Cancer.

ABSTRACT:

Importance

Luminal and basal subtypes of primary prostate cancer have been shown to be molecularly distinct and clinically important in predicting response to therapy. These subtypes have not been described in metastatic prostate cancer.

Objectives

To identify clinical and molecular correlates of luminal and basal subtypes in metastatic castration-resistant prostate cancer (mCRPC) and investigate differences in survival, particularly after treatment with androgen-signaling inhibitors (ASIs).

Design, setting, and participants

In this cohort study, a retrospective analysis was conducted of 4 cohorts with mCRPC (N = 634) across multiple academic centers. Treatment was at the physicians' discretion. Details of the study cohorts have been published elsewhere between 2016 a

SUBMITTER: Aggarwal R 

PROVIDER: S-EPMC8461554 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature