Diffusion MRI Captures White Matter Microstructure Alterations in PRKN Disease.

ABSTRACT:

Background

Although pathological studies usually indicate pure dopaminergic neuronal degeneration in patients with parkin (PRKN) mutations, there is no evidence to date regarding white matter (WM) pathology. A previous diffusion MRI study has revealed WM microstructural alterations caused by systemic oxidative stress in idiopathic Parkinson's disease (PD), and we found that PRKN patients have systemic oxidative stress in serum biomarker studies. Thus, we hypothesized that PRKN mutations might lead to WM abnormalities.

Objective

To investigate whether there are WM microstructural abnormalities in early-onset PD patients with PRKN mutations using diffusion tensor imaging (DTI).

Methods

Nine PRKN patients and 15 age- and sex-matched healthy controls were recruited. DTI m

SUBMITTER: Koinuma T 

PROVIDER: S-EPMC8461664 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature