Non-Genetic Risk Factors for Parkinson's Disease: An Overview of 46 Systematic Reviews.

ABSTRACT:

Background

Numerous systematic reviews (SRs) and meta-analyses on non-genetic risk factors for Parkinson's disease (PD) development have been published with inconsistent conclusions.

Objective

This overview of SRs aimed to summarize evidence on non-genetic factors for the development of PD from the published SRs, and explore the reasons behind the conflicting results.

Methods

Three international databases were searched for SRs with meta-analyses summarized evidence on non-genetic factors for PD development. The Assessing the Methodological Quality of Systematic Reviews 2 tool was used to appraise the methodological quality of included SRs. Pooled effect estimations were extracted from each meta-analysis.

Results

Forty-six SRs covered six categories, and more th

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8461677 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature