Which Neuropsychological Tests? Predicting Cognitive Decline and Dementia in Parkinson's Disease in the ICICLE-PD Cohort.

ABSTRACT:

Background

Cognitive impairment is common in Parkinson's disease (PD), with 80% cumulatively developing dementia (PDD).

Objective

We sought to identify tests that are sensitive to change over time above normal ageing so as to refine the neuropsychological tests predictive of PDD.

Methods

Participants with newly diagnosed PD (n = 211) and age-matched controls (n = 99) completed a range of clinical and neuropsychological tests as part of the ICICLE-PD study at 18-month intervals over 72 months. Impairments on tests were determined using control means (<1-2SD) and median scores. Mild cognitive impairment (PD-MCI) was classified using 1-2SD below normative values. Linear mixed effects modelling assessed cognitive decline, while Cox regression identified baseline predictor

SUBMITTER: Lawson RA 

PROVIDER: S-EPMC8461722 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature