Neuroticism, Smoking, and the Risk of Parkinson's Disease.

ABSTRACT:

Background

The relationship among neuroticism, smoking, and Parkinson's disease (PD) is less examined.

Objective

To examine the causal associations between neuroticism, smoking initiation, and the risk of PD.

Methods

We performed a two-sample Mendelian randomization (MR) design in a network framework. Summary statistics from meta-analyses of genome-wide association studies (GWAS) were based on large cohorts of European ancestry. Study participants were from various cohort studies for neuroticism and smoking initiation, and case-control studies or cohort studies of PD from previously published GWAS meta-analyses. Patients with PD were ascertained from either clinical visit or self-reported.

Results

The two-sample MR analysis showed no evidence for a causal assoc

SUBMITTER: Sieurin J 

PROVIDER: S-EPMC8461727 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature