Estimates of Intracellular Dopamine in Parkinson's Disease: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

The hallmark of Parkinson's disease is depletion of dopamine in the basal ganglia. Models of Parkinson's disease include dopamine as a contributor to disease progression. However, intraneuronal levels of dopamine have not been reported.

Objective

Meta-analytic methods were utilized to determine intracellular dopamine levels in Parkinson's disease.

Methods

A systematic review of the literature and frequentist meta-analyses were performed. Dopamine levels were scaled for cell and axon numbers as well as VMAT2 protein levels.

Results

Reduced tissue dopamine, dopaminergic cell bodies and VMAT2 protein were confirmed. The ratio of Parkinson's to normal brain intracellular dopamine scaled for either cell or axon number, each with VMAT2 level in the caudate

SUBMITTER: Sackner-Bernstein J 

PROVIDER: S-EPMC8461729 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature