A Proposal to Make Biomedical Research into Alzheimer's Disease More Democratic Following an International Survey with Researchers.

ABSTRACT:

Background

Therapeutic research into Alzheimer's disease (AD) has been dominated by the amyloid cascade hypothesis (ACH) since the 1990s. However, targeting amyloid in AD patients has not yet resulted in highly significant disease-modifying effects. Furthermore, other promising theories of AD etiology exist.

Objective

We sought to directly investigate whether the ACH still dominates the opinions of researchers working on AD and explore the implications of this question for future directions of research.

Methods

During 2019, we undertook an international survey promoted with the help of the Alzheimer's Association with questions on theories and treatments of AD. Further efforts to promote a similar study in 2021 did not recruit a significant number of participants.

SUBMITTER: Daly T 

PROVIDER: S-EPMC8461732 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature