Viability of diffuse large B-cell lymphoma cells is regulated by kynurenine 3-monooxygenase activity.

ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy that is the most common type of lymphoma in Japan. Previous studies have demonstrated that patients with DLBCL have a poor prognosis due to increased levels of indoleamine 2,3-dioxygnase and kynurenine (KYN). However, the roles of metabolites acting downstream of KYN and associated enzymes are not fully understood. The present study investigated the role of kynurenine 3-monooxygenase (KMO), which catalyzes the conversion of KYN to 3-hydroxykynurenine (3-HK), using serum samples from patients with DLBCL and human DLBCL cell lines with different KMO expression [STR-428 cells with high levels of KMO expression (KMO^high) and KML-1 cells with low levels of KMO expression (KMO^low)]. Seru

SUBMITTER: Morita N 

PROVIDER: S-EPMC8461759 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature