CMTM3 suppresses chordoma progress through EGFR/STAT3 regulated EMT and TP53 signaling pathway.

ABSTRACT:

Background

Chordomas are rare, slow-growing and locally aggressive bone sarcomas. At present, chordomas are difficult to manage due to their high recurrence rate, metastasis tendency and poor prognosis. The underlying mechanisms of chordoma tumorigenesis and progression urgently need to be explored to find the effective therapeutic targets. Our previous data demonstrates that EGFR plays important roles in chordoma development and CKLF-like MARVEL transmembrane domain containing (CMTM)3 suppresses gastric cancer metastasis by inhibiting the EGFR/STAT3/EMT signaling pathway. However, the roles and mechanism of CMTM3 in chordomas remain unknown.

Methods

Primary chordoma tissues and the paired adjacent non-tumor tissues were collected to examine the expression of CMTM3 by wester

SUBMITTER: Yuan W 

PROVIDER: S-EPMC8461898 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature