Association between chronic periodontitis and the risk of Alzheimer's disease: combination of text mining and GEO dataset.

ABSTRACT:

Background

Although chronic periodontitis has previously been reported to be linked with Alzheimer's disease (AD), the pathogenesis between the two is unclear. The purpose of this study is to analyze and screen the relevant and promising molecular markers between chronic periodontitis and Alzheimer's disease (AD).

Methods

In this paper, we analyzed three AD expression datasets and extracted differentially expressed genes (DEGs), then intersected them with chronic periodontitis genes obtained from text mining, and finally obtained integrated DEGs. We followed that by enriching the matching the matching cell signal cascade through DAVID analysis. Moreover, the MCODE of Cytoscape software was employed to uncover the protein-protein interaction (PPI) network and the matching hub

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC8461934 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature