[Synonymous Codon Usage-a Guide for Co-Translational Protein Folding in the Cell].

ABSTRACT: In the cell, protein folding begins during protein synthesis/translation and thus is a co-translational process. Co-translational protein folding is tightly linked to translation elongation, which is not a uniform process. While there are many reasons for translation non-uniformity, it is generally believed that non-uniform synonymous codon usage is one of the key factors modulating translation elongation rates. Frequent/optimal codons as a rule are translated more rapidly than infrequently used ones and vice versa. Over 30 years ago, it was hypothesized that changes in synonymous codon usage affecting translation elongation rates could impinge on co-translation protein folding and that many synonymous codons are strategically placed within mRNA to ensure a particular translation kinetics

SUBMITTER: Komar AA 

PROVIDER: S-EPMC8462064 | biostudies-literature | 2019 Nov-Dec

REPOSITORIES: biostudies-literature