Curvature-driven feedback on aggregation-diffusion of proteins in lipid bilayers.

ABSTRACT: Membrane bending is an extensively studied problem from both modeling and experimental perspectives because of the wide implications of curvature generation in cell biology. Many of the curvature generating aspects in membranes can be attributed to interactions between proteins and membranes. These interactions include protein diffusion and formation of aggregates due to protein-protein interactions in the plane of the membrane. Recently, we developed a model that couples the in-plane flow of lipids and diffusion of proteins with the out-of-plane bending of the membrane. Building on this work, here, we focus on the role of explicit aggregation of proteins on the surface of the membrane in the presence of membrane bending and diffusion. We develop a comprehensive framework that includes lip

SUBMITTER: Mahapatra A 

PROVIDER: S-EPMC8462121 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature