The cost of evolved constitutive lac gene expression is usually, but not always, maintained during evolution of generalist populations.

ABSTRACT: Beneficial mutations can become costly following an environmental change. Compensatory mutations can relieve these costs, while not affecting the selected function, so that the benefits are retained if the environment shifts back to be similar to the one in which the beneficial mutation was originally selected. Compensatory mutations have been extensively studied in the context of antibiotic resistance, responses to specific genetic perturbations, and in the determination of interacting gene network components. Few studies have focused on the role of compensatory mutations during more general adaptation, especially as the result of selection in fluctuating environments where adaptations to different environment components may often involve trade-offs. We examine whether costs of a mutation

SUBMITTER: Phillips KN 

PROVIDER: S-EPMC8462147 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature