Neurodegenerative Disease: Roles for Sex, Hormones, and Oxidative Stress.

ABSTRACT: Neurodegenerative diseases cause severe impairments in cognitive and motor function. With an increasing aging population and the onset of these diseases between 50 and 70 years, the consequences are bound to be devastating. While age and longevity are the main risk factors for neurodegenerative diseases, sex is also an important risk factor. The characteristic of sex is multifaceted, encompassing sex chromosome complement, sex hormones (estrogens and androgens), and sex hormone receptors. Sex hormone receptors can induce various signaling cascades, ranging from genomic transcription to intracellular signaling pathways that are dependent on the health of the cell. Oxidative stress, associated with aging, can impact the health of the cell. Sex hormones can be neuroprotective under low oxidat

SUBMITTER: Sumien N 

PROVIDER: S-EPMC8462383 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature