Effect of Colchicine on Myocardial Injury in Acute Myocardial Infarction.

ABSTRACT:

Background

Inflammation is a key factor of myocardial damage in reperfused ST-segment-elevation myocardial infarction. We hypothesized that colchicine, a potent anti-inflammatory agent, may reduce infarct size (IS) and left ventricular (LV) remodeling at the acute phase of ST-segment-elevation myocardial infarction.

Methods

In this double-blind multicenter trial, we randomly assigned patients admitted for a first episode of ST-segment-elevation myocardial infarction referred for primary percutaneous coronary intervention to receive oral colchicine (2-mg loading dose followed by 0.5 mg twice a day) or matching placebo from admission to day 5. The primary efficacy outcome was IS determined by cardiac magnetic resonance imaging at 5 days. The relative LV end-diastolic volume ch

SUBMITTER: Mewton N 

PROVIDER: S-EPMC8462445 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature