Reproductive period and preclinical cerebrospinal fluid markers for Alzheimer disease: a 25-year study.

ABSTRACT:

Objective

The aim of the study was to examine the association between reproductive period, as an indicator of endogenous estrogen, and levels of cerebrospinal fluid (CSF) biomarkers for Alzheimer disease (AD).

Methods

A population-based sample of women from Gothenburg, Sweden was followed from 1968 to 1994 (N = 75). All women had natural menopause and were free from dementia. Information on reproductive period (age at menarche to age at menopause) was obtained from interviews from 1968 to 1980. Lumbar puncture was performed from 1992 to 1994 and CSF levels of Aβ42, Aβ40, P-tau, and T-tau were measured with immunochemical methods. Linear regression models adjusted for potential confounders were used to analyze the relationship between reproductive period and CSF biomarkers fo

SUBMITTER: Najar J 

PROVIDER: S-EPMC8462446 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature