Prevention of Colon Cancer Recurrence From Minimal Residual Disease: Computer Optimized Dose Schedules of Intermittent Apoptotic Adjuvant Therapy.

ABSTRACT:

Purpose

Adjuvant chemotherapy is used after surgery for stages II and III colorectal cancer to reduce recurrence. Nevertheless, recurrence may occur years later with the emergence of initially undetected minimal residual disease (MRD). Attempts to reduce recurrence by increasing the dose intensity and increasing the time of adjuvant therapy have been limited by the adverse effects of the recommended cytotoxic agents. The goals of this study were to suggest an alternative to the recommended cytotoxic agents and to determine optimal adjuvant therapy dose schedules that would reduce the percentage of recurrence at 5 years while retaining colon crypt function.

Methods

A total of 84,400 dose schedules with different duration, interval between doses, and intensity of treatment wer

SUBMITTER: Cockrell C 

PROVIDER: S-EPMC8462567 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature