BOIN Suite: A Software Platform to Design and Implement Novel Early-Phase Clinical Trials.

ABSTRACT:

Purpose

Using novel Bayesian adaptive designs has great potential to improve the efficiency of early-phase clinical trials. A major barrier for clinical researchers to adopt novel designs is the lack of easy-to-use software. Our purpose is to develop a user-friendly software platform to implement novel clinical trial designs that address various challenges in early-phase dose-finding trials.

Methods

We used R Shiny to develop a web-based software platform to facilitate the use of recent novel adaptive designs.

Results

We developed a web-based software suite, called Bayesian optimal interval (BOIN) suite, which includes R Shiny applications to handle various clinical settings, including single-agent phase I trials with and without prior information, trials with

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC8462603 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature