Toward Personalized Radiation Therapy of Liver Metastasis: Importance of Serial Blood Biomarkers.

ABSTRACT:

Purpose

To assess the added value of serial blood biomarkers in liver metastasis stereotactic body radiation therapy (SBRT).

Materials and methods

Eighty-nine patients were retrospectively included. Pre- and midtreatment blood samples were analyzed for potential biomarkers of the treatment response. Three biomarker classes were studied: gene mutation status, complete blood count, and inflammatory cytokine concentration in plasma. One-year local failure (LF) and 2-year overall survival (OS) were chosen as study end points. Multivariate logistic regression was used for response prediction. Added predictive benefit was assessed by quantifying the difference between the predictive performance of a baseline model (clinicopathologic and dosimetric predictors) and that of the bioma

SUBMITTER: Ajdari A 

PROVIDER: S-EPMC8462658 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature