Concordance probability as a meaningful contrast across disparate survival times.

ABSTRACT: The performance of time-to-event models is frequently assessed in part by estimating the concordance probability, which evaluates the probabilistic pairwise ordering of the model-based risk scores and survival times. The standard definition of this probability conditions on any survival time pair ordering, irrespective of whether the times are meaningfully separated. Inclusion of survival times that would be deemed clinically similar attenuates the concordance and moves the estimate away from the contrast-of-interest: comparing the risk scores between individuals with disparate survival times. In this manuscript, we propose a concordance definition and corresponding method to estimate the probability conditional on survival times being separated by at least a minimum difference. The propos

SUBMITTER: Devlin SM 

PROVIDER: S-EPMC8462660 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature