Mathematical model of a personalized neoantigen cancer vaccine and the human immune system.

ABSTRACT: Cancer vaccines are an important component of the cancer immunotherapy toolkit enhancing immune response to malignant cells by activating CD4+ and CD8+ T cells. Multiple successful clinical applications of cancer vaccines have shown good safety and efficacy. Despite the notable progress, significant challenges remain in obtaining consistent immune responses across heterogeneous patient populations, as well as various cancers. We present a mechanistic mathematical model describing key interactions of a personalized neoantigen cancer vaccine with an individual patient's immune system. Specifically, the model considers the vaccine concentration of tumor-specific antigen peptides and adjuvant, the patient's major histocompatibility complexes I and II copy numbers, tumor size, T cells, and anti

SUBMITTER: Rodriguez Messan M 

PROVIDER: S-EPMC8462726 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature