The cohesin stabilizer Sororin drives G2-M transition and spindle assembly in mammalian oocytes.
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ABSTRACT:
SUBMITTER: Zhou C
PROVIDER: S-EPMC8462903 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
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The cohesin stabilizer Sororin drives G<sub>2</sub>-M transition and spindle assembly in mammalian oocytes.
Zhou Changyin C Zhang Xue X Miao Yilong Y Zhang Yu Y Li Yu Y Xiong Bo B
Science advances 20210924 39
During the S phase of mitosis, Sororin is recruited by acetylated Smc3 and stabilizes sister chromatid cohesion by counteracting the Wapl-Pds5 interaction. Thereafter, Sororin is phosphorylated during prophase and translocated to the cytoplasm, where its function remains poorly understood. Here, we report that Sororin acts as a regulator of meiotic G<sub>2</sub>-M transition and spindle assembly in mammalian oocytes. Sororin is present in the nucleus of GV oocytes and becomes associated with the ...[more]
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