UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival.
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ABSTRACT:
SUBMITTER: Lee L
PROVIDER: S-EPMC8462904 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival.
Lee Lara L Perez Oliva Ana Belen AB Martinez-Balsalobre Elena E Churikov Dmitri D Peter Joshua J Rahmouni Dalicya D Audoly Gilles G Azzoni Violette V Audebert Stephane S Camoin Luc L Mulero Victoriano V Cayuela Maria L ML Kulathu Yogesh Y Geli Vincent V Lachaud Christophe C
Science advances 20210924 39
Ubiquitin-fold modifier 1 (UFM1) is involved in neural and erythroid development, yet its biological roles in these processes are unknown. Here, we generated zebrafish models deficient in <i>Ufm1</i> and <i>Ufl1</i> that exhibited telomere shortening associated with developmental delay, impaired hematopoiesis and premature aging. We further report that HeLa cells lacking UFL1 have instability of telomeres replicated by leading-strand synthesis. We uncover that MRE11 UFMylation is necessary for t ...[more]
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