Age and eczema severity, but not family history, are major risk factors for peanut allergy in infancy.

ABSTRACT:

Background

Whether to screen high-risk groups before early peanut introduction is controversial.

Objective

We sought to determine the risk of peanut allergy (PA) before peanut introduction for infants with (1) moderate-severe eczema, (2) another food allergy (FA), and/or (3) a first-degree relative with peanut allergy (FH).

Methods

Infants aged 4 to 11 months with no history of peanut ingestion, testing, or reaction and at least 1 of the above risk factors received peanut skin prick test and, depending on skin prick test wheal size, oral food challenge or observed feeding.

Results

A total of 321 subjects completed the enrollment visit (median age, 7.2 months; 58% males); 78 had eczema only, 11 FA only, 107 FH only, and 125 had multiple risk factors. Overall, 18

SUBMITTER: Keet C 

PROVIDER: S-EPMC8462937 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature