Neuronal calcium sensor 1 (NCS1) dependent modulation of neuronal morphology and development.

ABSTRACT: Calcium (Ca²⁺ ) signaling is critical for neuronal functioning and requires the concerted interplay of numerous Ca²⁺ -binding proteins, including neuronal calcium sensor 1 (NCS1). Although an important role of NCS1 in neuronal processes and in neurodevelopmental and neurodegenerative diseases has been established, the underlying mechanisms remain enigmatic. Here, we systematically investigated the functions of NCS1 in the brain. Using Golgi-Cox staining, we observed a reduction in dendritic complexity and spine density in the prefrontal cortex and the dorsal hippocampus of Ncs1^-/- mice, which may underlie concomitantly observed deficits in memory acquisition. Subsequent RNA sequencing of Ncs1^-/- and Ncs1^+/+ mouse brain tissues revealed

SUBMITTER: Fischer TT 

PROVIDER: S-EPMC8462996 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature