Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes.

ABSTRACT: Tissue-resident intestinal intraepithelial T lymphocytes (T-IEL) patrol the gut and have important roles in regulating intestinal homeostasis. T-IEL include both induced T-IEL, derived from systemic antigen-experienced lymphocytes, and natural T-IEL, which are developmentally targeted to the intestine. While the processes driving T-IEL development have been elucidated, the precise roles of the different subsets and the processes driving activation and regulation of these cells remain unclear. To gain functional insights into these enigmatic cells, we used high-resolution, quantitative mass spectrometry to compare the proteomes of induced T-IEL and natural T-IEL subsets, with naive CD8⁺ T cells from lymph nodes. This data exposes the dominant effect of the gut environment over on

SUBMITTER: Brenes AJ 

PROVIDER: S-EPMC8463072 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature