Olaparib Inhibits Tumor Growth of Hepatoblastoma in Patient-Derived Xenograft Models.

ABSTRACT:

Background and aims

Hepatoblastoma (HBL) is a devastating pediatric liver cancer with multiple treatment options, but it ultimately requires surgery for a cure. The most malicious form of HBL is a chemo-resistant aggressive tumor that is characterized by rapid growth, metastases, and poor response to treatment. Very little is known of the mechanisms of aggressive HBL, and recent focuses have been on developing alternative treatment strategies. In this study, we examined the role of human chromosomal regions, called aggressive liver cancer domains (ALCDs), in liver cancer and evaluated the mechanisms that activate ALCDs in aggressive HBL.

Results

We found that ALCDs are critical regions of the human genome that are located on all human chromosomes, preferentially in intronic

SUBMITTER: Johnston ME 

PROVIDER: S-EPMC8463483 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature