Sex Differences in the Human Brain Transcriptome of Cases With Schizophrenia.

ABSTRACT:

Background

While schizophrenia differs between males and females in the age of onset, symptomatology, and disease course, the molecular mechanisms underlying these differences remain uncharacterized.

Methods

To address questions about the sex-specific effects of schizophrenia, we performed a large-scale transcriptome analysis of RNA sequencing data from 437 controls and 341 cases from two distinct cohorts from the CommonMind Consortium.

Results

Analysis across the cohorts identified a reproducible gene expression signature of schizophrenia that was highly concordant with previous work. Differential expression across sex was reproducible across cohorts and identified X- and Y-linked genes, as well as those involved in dosage compensation. Intriguingly, the sex expressi

SUBMITTER: Hoffman GE 

PROVIDER: S-EPMC8463632 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature