Admission serum myoglobin and the development of acute kidney injury after major trauma.

ABSTRACT:

Background

Myoglobin and creatine kinase (CK) are both established markers of muscle injury but their hospital admission values have never been compared to predict post-traumatic acute kidney injury (AKI).

Methods

An observational registry study of consecutive trauma patients admitted to a major regional trauma centre. The primary outcome was stage 1 or more AKI in the first 7 days after trauma. We assessed the association of hospital admission myoglobin or CK with development of AKI both alone and when added to two existing risk prediction models for post traumatic AKI.

Results

Of the 857 trauma patients (median age 36 [25-52], 96% blunt trauma, median ISS of 20 [12-47]) included, 102 (12%) developed AKI. Admission myoglobin performed better than CK to predict AKI an

SUBMITTER: Tarazona V 

PROVIDER: S-EPMC8463647 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature