Assessing concordance between patient-reported and investigator-reported CTCAE after proton beam therapy for prostate cancer.

ABSTRACT:

Purpose

We report acute patient-reported outcomes using CTCAE (PRO-CTCAE) of proton beam radiotherapy for high-risk or unfavorable intermediate-risk prostate cancer in a prospective clinical trial. PRO-CTCAE were correlated with investigator reported-CTCAE (IR-CTCAE) to assess the degree of concordance.

Methods and materials

11 PRO-CTCAE questions assessed gastrointestinal (GI), genitourinary (GU), or erectile function side effects. The correlation scheme between PRO-CTCAE and IR-CTCAE was independently developed by two physicians. Analyses of PRO-CTCAE and IR-CTCAE were conducted using both descriptive terms and the converted grade scores. The Kappa statistic described the degree of concordance.

Results

55 patients were included. IR-CTCAE underestimated diarrhea comp

SUBMITTER: Kowalchuk RO 

PROVIDER: S-EPMC8463742 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature